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KMID : 0377619720220030264
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Korean Jungang Medical Journal
1972 Volume.22 No. 3 p.264 ~ p.266
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Oral Proteolytic Enzyme Theray(Chymoral) in Episiotomy Patients
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申冕雨/Shin, Myon Woo
李珍鏞/金基宗/朴貞範/Lee, Jin Yong/Kim, Kee Chong/Park, Jung Bum
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Abstract
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Chymotrypsin is an endopeptidase, fractionated from bovine pancreas, by modification of the Kunitz and Northrop method. Innerfield observed that intravenously administered trypsin induced lytic effect on artificially formed intravascular thrombi in animal experiments. More recent data suggest that chymotrypsin(parenteral or buccal) may be successfully used to prevent tie pain, edema and ecchymosis of episiotomy wounds. Preliminary studies of several authors indicate that chymoral has clinical effectiveness exactly parallel of that obtainable with the parenteral and buccal forms of chymotrypsin. This proteolytic enzymes are increasing interest and have been widely employed clinically as anti-inflammatory and antiedemic remedies.
The double-blind study was carried out in 100 obstetric patients to determine clinical effectiveness of chymoral to aid in relieving edema, pain and ecchymosis following perineal laceration or episiotomy.
The result of the study are as follows.
1. Chymoral proved to be an effective drug in reducing edema during the 3 postpartum days when it is most marked.
2. Pain. and ecchymosis were also considerably reduced in treated group.
3. There was no complete absence of side effects which could be ascribed to the drug.
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